Cytotoxic activity evaluation of chalcones on human and mouse cell lines
نویسندگان
چکیده
Background The Brazilian National Cancer Institute (INCA) estimated last year almost forty thousand new cancer cases of laryngeal carcinoma, melanoma, tracheal, bronchial and lung cancer. It is known that multidrug resistance and unspecific toxicity are the major challenges for commercial anticancer drugs [1]. In this regard, natural compounds and derivatives are considered as a source of novel antitumor drugs. Among these molecules, chalcones have gained pharmacological importance due its mechanisms of action related to apoptosis induction [2]. Here we characterized the cytotoxicity of four chalcones toward three tumor cell lines: Hep-2 (human laryngeal squamous carcinoma cells), B-16 (mouse melanoma), A549 (human lung adenocarcinoma epithelial cells) and one normal cell line: 3T3 (mouse fibroblasts).
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